Design and synthesis of novel anti-cancer curcumin derivatives: Investigation of anti-cancer properties against HepG2 cell line
نویسندگان
چکیده
The new anti-cancer and water-soluble curcumin derivatives have been synthesized solvent-freely by functionalizing the phenolic group of with various NH compounds to increase water solubility cancerous properties. biological applications drugs investigated against highly potent HepG2 carcinoma cell line. studies showed that could be used in low concentrations (µM/l&lt;1) avoid anti-apoptotic properties cell. Also, designed molecules below 1 µM/l a good percentage viability 31.5, 45.3, 66.7% HepG2<em> </em>cells. Furthermore, FTIR 1H, 13CNMR spectroscopy fully characterized derivatives.
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ژورنال
عنوان ژورنال: Mediterranean Journal of Chemistry
سال: 2023
ISSN: ['2028-3997']
DOI: https://doi.org/10.13171/mjc02303171651mosaddegh